Polymannose: Jewel of Aloe Vera Gel
by Scott Siegel
In the 1980's, scientists biochemists began to explore
the properties of Aloe Vera. Their research led to the discovery of a
group of polysaccharides known as Aloe polymannose.
Dr. Ian R. Tizard, an emminent immunologist, "Although common
polysaccharides such as starch, dextran, and insulin do not have
anti-tumour activity, there is abundant evidence that some mannans
[including polymannans] are very potent anti-cancer agents."
polymannose are complex sugars consisting of two mannose molecules and
one glucose molecule. These polymannose are composed of different
molecular lengths, weights, and sizes. Lengths vary from short, medium,
large, and very large. Within these parameters, each size molecule
performs it own unique function in the body.
Imagine a pearl
necklace. The heavier, longer in length, and larger the pearls, the more
valuable the necklace. Imagine now that these pearls are actually
individual mannans. The heavier and longer the chain of polymannans, the
more vital and valuable the function performed in the body. In short,
there are 4 chain lengths: short, medium, large, and very large. The
very large chain length, with the heaviest molecular weight, is referred
to as the Acemannan Fraction. It is these very large molecules that
cause the body to produce a natural chemical, tumor necrosis factors,
that shuts off blood supply to tumors.
According to The Scientist
(April 29, 2002), "these macromolecules affect cell-cell interactions,
immune function, and protein regulation, and disruption of their
[presence in the body] results in disease..."
understood Aloe Vera to be an effective healing substance. Their
understanding was largely based on observation and experience, on
generations of trial and error. Today modern science has validated, from
a molecular perspective, that the healing properties found in Aloe's
inner gel can be traced to polymannose.
What sparked the
interest of the scientific community in this particular complex molecule
in the first place was its ability to enhance the body's immune system
when ingested-and to do so without harmful side effects.
In fact, a
relatively new field of scientific study interested in the focusing on carbohydrate
research has emerged: glycobiology . Scientists are especially in the key sugars, or glyconutrients, and phytochemicals
contained within the Aloe gel.
In the 1990's, scientists
discovered 200 sugar molecules found in nature. Of these 200 sugar
molecules, the body requires 8 key sugars that support cell to cell
communication. These 8 key sugars help the body properly synthesize
bioactive molecules required in protein regulation. In fact, 7 of the 8
key sugars are found in the Aloe Vera inner gel; of these sugars, the
most important or the
master sugar glyconutrient is the polymannose (mannose). Why?
Because the body's receptor sites are waiting for this particular
molecule, the mannose molecule, to dock there in order to start
biological processes. The real importance of this "docking" is for
immune recognition; that is, recognizing that which is self or other,
that which is friendly or invasive (for example, viruses, parasites,
etc.) It is the only sugar found in nature that is not broken down by
any enzyme. Furthermore, mannose is totally engulfed into the cell
through a process known as endocytosis. Mannose is guided to very
primitive receptor sites on each and every cell-from a hepatic cell to a
brain cell. These sites, exclusive to mannose, are called MP6 (mannose
Once polymannose were detected in Aloe
Vera, researchers noted that the varying chain length sizes of
polymannose produce different healing properties. For example:
Short Chain Length
Small Molecular Weight: Reduces inflammation, provides digestive support, and balances blood sugar regulation.
Medium Chain Length
Medium Molecular Weight: Very effective intracellular antioxidants and free radical scavengers.
Large Chain Length
Large Molecular Weight: Has a direct anti-bacterial, anti-fungal, anti-parasitic and anti-viral effect.
Very Large Chain Length
Large Molecular weight: The very large molecules [also referred to as
acemannans or Acemannan Fraction ] are immune modulating. They
orchestrate a cascade of immune responses resulting in an enhanced
activation of general host defense, tissue remodeling and healing for up
regulation under active and down regulation over active immune systems.
other plants, Aloe Vera contains all FOUR chain lengths, instead of
three. Again, the presence of the fourth (Acemannan Fraction, with its
very large chain length) makes all the difference.
Aloe Vera is not
the only nutritive substance containing polymannose,. In fact, we
should be receiving polymannose through the consumption of wheat and
rice. However, the development of hybrid seeds, the use of poor farming
practices, and the marketing of overly processed foods have sabotaged
the nutritive value of our diets. Even if products are labeled
"organic," one could never eat a large enough quantity of the organic
food in question to meet the body's immune system mannose
Add to this the emotional, mental, and physical
stress inherent in daily life-as well as taxing environmental
factors-and one begins to understand the profound level of support
required by our immune systems.
Until very recently, most Aloe
products available on the market were either highly processed or
processed incorrectly, and therefore devoid of the highly prized, very
large-sized polymannose. At 4R Health Products,
Aloe Immune is processed according to the most sensitive methods
possible-stabilizing these precious molecules and passing their maximum
benefits on to you.
The U.S. Adopted Name Council gave one product the generic drug name "acemannan."
The product statements have not been
evaluated by FDA and the products are not intended to diagnose, treat,
cure or prevent any disease or medical condition. Contents of this
website are for informational purposes should not be used for diagnosing
or treating a health problem or disease.