Aloe Science & Regulation of Immunity |
by Dr. R. Siegel M.D. |
Our body has an innate capacity to defend and heal
itself. We are now in an age for understanding the inborn,
self-regulating, natural ability of our immune system. Much as the
earlier clinician examined the body with external stethoscope and
otoscope, today we use the modern tools of the biochemical/molecular
laboratory to exam the inner conditions of the body. Armed with high
tech electron and photon microscopes for instance, we study specially
stained cross tissue for cellular changes. Coordinated with clinical
observation and the process for cellular and humoral integration and
healing.
In a summary paper by bio-pathologist Dr. Reg McDaniel
MD, a highly coordinated sequence of immune events can be traced:
recognizing the flow of macrophage activation, an army of efficient
immune molecules, T and B elements, cytokine immune messengers, gene
activation, response of protein synthesis and cellular remodeling and
appropriate feedback loops such a reset and gene suppression. Notable is
the role of the large immune supervisor- the monocyte/macrophage, or
M/Ms-which wanders through the extracellular fluids, constantly
monitoring [touching, feeling] the condition of tissues for organ
damage, infection, malignancy, and aging.
The history of M/Ms date
back to the early 1800's, when Behring discovered humoral substances in
serum capable of defense, eventually to be studied as antibodies,
complements and acute reactive-phase proteins. He saw a blend of immune
agents that protected animals from disease by deactivating the toxins
of bacteria. Later experiments by Metchnikoff showed the role of
leukocytes, engulfing and destroying microscopic organisms. It was then
recognized that both humoral [chemical] molecules and immune cells
mediate the host defense.
William Cooley in 1891 cured soft tissue
malignant sarcomas, using an anti-tumor fraction akin to what we see
today as toxic shock. His particular toxin- a polysaccharide released
from bacterial membranes- proved too toxic for human treatment. An idea
was born. Particular polysaccharides serving as a major sponsor can
trigger a cascade of immune-inflammation that even cures tumors.
Recently, it has been discovered that an analogous molecule, the plant
molecule of beta-polysaccharide, can act as a critical precursor of
immunity: triggering the macrophage that, in turn, both calls out the
army of the immune system and in addition, safely orchestrates the over
all defense of the body.
A vast array of humoral chemicals and
cells respond to the macrophage. That is, the giant macrophage, much
like a five star General Patton, orchestrates and modulates the various
elements of the immune system. These types of immune "troops" recognized
today include helper and suppressor killer antibody types of T and B
cells, humoral chemicals such as leukocytes [within the ground
regulatory system] to initiate the defense activities of phagocytosis,
lysosomal enzymes, cytolysis, etc. In turn, cytokine messenger molecules
"talk" to membrane receptors of the host cells which then send
secondary signals into the particular proteins needed to defend and to
repair dysfunctional tissue. Moreover, the host genes can even program a
remodeling of the membranes of attack cells, defeating their attempts,
for instance to dock with immune CD's.
The most recent laboratory
findings demonstrate that it is the core molecular sequence of the
mannan component of cell membrane structures that serves as a first
level signal to stimulate the release of M/Ms, both in animal and human
cell lines and that these giant macrophages serve in turn as the primal
surveyor and coordinator, of the total dynamic immune process. Extensive
reviews of pharmaceutical research show the initial effects of M/Ms, to
target, induce and modulate over 100 cell activities and cytokines,
including enhanced production, in a dose-related manner, of
interleukin-1 [IL-1] prostaglandin E-2 [PGE-2] lymphocyte CD4, natural
killer and CD8 lymphocytes, Staphylococcal phagocytosis and tumor cell
destruction. The Regulation of Immunity
An
M/M command cell [mono-macrophage] emerges from the sinuses of the
spleen, liver and bone marrow to circulate and migrate into tissues or
organ cavities. They locate in greater numbers in the skin, mucosa, and
other strategic portals of common invasion. The M/Ms technique is to
analyze structures on the cell surface [oligosaccharides chains of
glycoprotein] to differentiate cells of Self, non-Self or
damaged/altered Self. The M/ Ms are triggered into activation if they
recognize a critical sequence of the membrane saccharides as being an
abnormal non-Self or damaged/altered Self. If so, they audit ongoing
multiple cellular mechanisms which sense and induce enzymes to destroy
the "errors" [such as assembly errors in glycosylation] by targeting
signals of IL-1, 54, INF-G, 55, and RNF etc. Assayed by ELISA
techniques, M/Ms induce production on a concentration gradient basis of
PG-E2 24, IL-1B, IL-2, IL-6, THF-alpha, GM-CSF, I~F-alpha and INF-Gamma
57, are shown to modulate defense and repair, and are sensitive to the
simultaneous time/zone/sequence needs of tissue.
Mannose polymers
produce a dose dependent increase of cell proliferation in culture
medium. The hydrolased cleaved mannose units [ex. the Mannose molecule]
enhance cell growth of human stromal fibroblasts and parenchyma cells
of cat kidney. Also, it alerts genetic alteration of the structural
membrane envelope of an attack virus, obstructing the chance for viral
host cell docking. The enhanced growth of human stromal fibroblasts
suggests that the ground regulatory system serves as the initial action
site/vehicle of induced immune behavior. To sum, biological functions
are mediated by the advanced macrophage that in turn can be stimulated
by the polymannan molecule. Mannose molecules are components of the
surface membranes of cells and are responsible for essential complex
biochemical activities of cell life. The molecular structure of the
cellular membrane in plants and animals is synthesized upon a core of
mannose molecules. It is a gene dictated saccharides that ultimately can
be read as cell signature and can be selectively responded,
immunologically.
Mannan serves as a universal agent for
stimulating the macrophage and in turn, the immune system. Its functions
are essential for good health and defense. The beta-mannose-6-P04 of
plant cell origin is a relatively nontoxic analogue of the [toxic]
bacterial cell membrane first used by Dr. Cooley. The functional
polymannan represents the first safe molecule in the new scientific
field known as Glycobiology or Glycoscience. It meets the standards
imposed by new government legislation, classified as Nutraceutical.
Mannans
are relatively rare in common western diets. The body has a critical
conservation of metabolic, low molecular weight mannans. Specific
transport molecules [mannose binding proteins MBP] are produced in the
liver of higher order animals. Research on the polymannan molecule
supported scientifically by over $70 million in research studies, is the
only functional molecule of Aloe. Aloe Immune TM is organically grown
aloe and with a very unique dehydration process to retain all four
chains of molecular weight polymannans found in aloe. Independent Labs
have shown Aloe Immune TM aloe to have
higher concentrations of the largest molecular weight polymannans,
Acemannan (Barbadensis Miller species) to have over 1,000,000 - 9,000,000 Daltons.
The polymannan molecule commands the position
of Nutraceutical health care, acting to orchestrate [upgrade and
downgrade] the immune modulation process. It enhances the host defense
against a broad array of biological immune assaults, including allergy
and hypersensitivity, auto-immune diseases, wound healing, induction of
necrosis in malignant tumors and micro viral and bacterial infections.
The pharmaceutical grade ACE-Mannan has been proven for safety and is
accepted by the USDA for animal treatment of tumors and by the FDA for
oral and skin treatment in humans. Currently controlled research is in
process, per the FDA protocol for treatment of twenty types of human
cancer and digestive ulceration disease.
The product
statements have not been evaluated by FDA and the products are not intended to
diagnose, treat, cure or prevent any disease or medical condition. Contents of
this website are for informational purposes should not be used for diagnosing
or treating a health problem or disease.
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